Across TCGA patient cohorts, TRDN mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRDN-associated genes across cancer lineages are MEK1, p62 Lck ligand, and PCNA. Each is linked with TRDN in more than 1 cancer types. Because this analysis shows association rather than direction, both TRDN-to-partner and partner-to-TRDN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRDN→partner) and Y-score (partner→TRDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.435	+4.087	<.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.238	+1.512	.017	.017	3	2
UCEC	PCNA →	+0.194	+1.473	.003	.006	3	2
UCEC	4E-BP1 →	+0.284	+3.807	<.001	<.001	3	2
LUSC	PREX1 →	-0.196	-3.312	.032	.010	3	1
LUSC	Di-Ras3 →	+0.118	+2.179	.013	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Exploration

TRDN survival (RNA) · tumor vs normal (RNA) · all TRDN data types