Across TCGA cell cohorts, TRDN mutation is significantly associated with the RNA expression of many other genes, with 154 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRDN-associated genes across cancer lineages are NEU2, RD3L, and FAM25A. Each is linked with TRDN in more than 1 cancer types. Because this analysis shows association rather than direction, both TRDN-to-partner and partner-to-TRDN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRDN→partner) and Y-score (partner→TRDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	NEU2 →	+0.239	+3.584	.006	.005	3	2
STOMACH	RD3L →	+0.061	+4.129	<.001	.007	3	2
LUNG_SCLC	FAM25A →	+0.140	+4.643	<.001	.004	3	2
LUNG_SCLC	OR8B3 →	+0.019	+4.044	.005	.009	3	2
URINARY_TRACT	PRAMEF12 →	+0.027	+4.050	<.001	.002	3	1
URINARY_TRACT	OR4N2 →	+0.037	+3.584	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 154 associations by consensus.

Exploration

TRDN survival (RNA) · tumor vs normal (RNA) · all TRDN data types