Across TCGA cell cohorts, TRDN mutation is significantly associated with the mutation status of many other genes, with 3,694 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRDN-associated genes across cancer lineages are RAI1, MDN1, and SORL1. Each is linked with TRDN in more than 4 cancer types. Because this analysis shows association rather than direction, both TRDN-to-partner and partner-to-TRDN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRDN→partner) and Y-score (partner→TRDN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RAI1 →	+2.565	+3.774	<.001	<.001	1	5
LARGE_INTESTINE	MDN1 →	+1.510	+2.652	<.001	<.001	1	5
OVARY	SORL1 →	+3.562	+4.684	.002	.002	1	5
BLOOD_Leukemia	FBN3 →	+2.124	+3.366	.003	.003	1	5
BLOOD_Leukemia	HUWE1 →	+3.050	+5.129	<.001	<.001	1	4
OVARY	RAPGEF4 →	+3.977	+4.930	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,694 associations by consensus.

Exploration

TRDN survival (RNA) · tumor vs normal (RNA) · all TRDN data types