TRDN-AS1

Across TCGA pan-cancer cohorts, TRDN-AS1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated TRDN-AS1 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TRDN-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TRDN-AS1 expression acts as an unfavorable survival marker, although some lineages such as LGG and COAD show a favorable association.

CESC, MESO, and THCA are the cancer types where TRDN-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Tertile	IV	0.226	0.630	.012	36	view →
MESO	DFS	Tertile	II,III,IV	0.232	0.538	.027	24	view →
THCA	DFS	Tertile	III,IV	0.540	0.802	.020	21	view →
SKCM	OS	Tertile	All	0.255	0.337	.026	12	view →
LGG	OS	Median	All	0.938	0.855	<.001	12	view →
COAD	DFS	Tertile	III,IV	1.000	0.610	.012	12	view →
GBM	OS	Tertile	All	0.274	0.456	.019	9	view →
KIRC	DFS	Quartile	III,IV	0.294	0.521	.010	9	view →
BLCA	DFS	Tertile	All	0.750	0.541	.044	6	view →
KICH	OS	Tertile	All	0.555	0.913	.015	6	view →
OV	OS	Tertile	IV	0.765	0.566	.044	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

TRDN-AS1–CESC (OS)

Open the CESC breakdown →