Across TCGA pan-cancer cohorts, TRDJ2 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TRDJ2’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where TRDJ2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRDJ2 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.
KICH, KIRC, and THCA are the cancer types where TRDJ2 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRDJ2 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.