TRDC

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TRDC mutation is significantly associated with the RNA expression of many other genes, with 127 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRDC-associated genes across cancer lineages are RNA5SP414, RNA5SP411, and MIR514B. Each is linked with TRDC in more than 1 cancer types. Because this analysis shows association rather than direction, both TRDC-to-partner and partner-to-TRDC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRDC→partner) and Y-score (partner→TRDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRNA5SP414 →+0.748+2.933<.001.00632
UCECRNA5SP411 →+1.289+2.715.001.00632
BRCAMIR514B →+0.418+8.471<.001.00532
SKCMRN7SL705P →+0.077+4.475<.001.00532
UCECTRAJ42 →+1.207+3.454<.001<.00132
LUSCRNA5SP419 →+1.034+6.102<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 127 associations by consensus.

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