Across TCGA patient cohorts, TRDC mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRDC-associated genes across cancer lineages are Myosin-IIa, VHL, and p62 Lck ligand. Each is linked with TRDC in more than 1 cancer types. Because this analysis shows association rather than direction, both TRDC-to-partner and partner-to-TRDC results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRDC→partner) and Y-score (partner→TRDC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa →	+0.234	+3.007	.028	.019	3	1
UCEC	VHL →	-0.887	-3.000	.023	.036	3	1
UCEC	p62 Lck ligand →	+0.398	+2.817	.034	.036	2	1
UCEC	Annexin-1 →	+0.603	+3.000	.047	.037	1	1
UCEC	Caspase-7-cleavedD198 →	+1.305	+3.000	<.001	.037	1	1
UCEC	Di-Ras3 →	-0.189	-3.000	.028	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

TRDC survival (RNA) · tumor vs normal (RNA) · all TRDC data types