TRBV7-4

Across TCGA pan-cancer cohorts, TRBV7-4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TRBV7-4 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRBV7-4 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRBV7-4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where TRBV7-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.729	0.592	<.001	129	view →
SKCM	OS	Median	All	0.418	0.280	<.001	107	view →
LUAD	DFS	Median	All	0.730	0.600	<.001	96	view →
UVM	DFS	Tertile	All	0.290	0.684	<.001	78	view →
CESC	OS	Tertile	All	0.859	0.684	<.001	58	view →
STAD	DFS	Median	II,III,IV	0.612	0.445	.001	51	view →
ESCA	DFS	Tertile	II,III,IV	0.501	0.286	.009	36	view →
BLCA	OS	Quartile	III,IV	0.754	0.610	.014	35	view →
BRCA	DFS	Tertile	All	0.524	0.471	.002	32	view →
PAAD	DFS	Tertile	II,III,IV	0.551	0.321	.009	29	view →
LUSC	DFS	Median	III,IV	0.655	0.345	.001	19	view →
LGG	OS	Tertile	All	0.675	0.867	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TRBV7-4–HNSC (OS)

Open the HNSC breakdown →