Across TCGA pan-cancer cohorts, TRBV7-3 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TRBV7-3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV7-3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV7-3 is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

KIRC, BRCA, and UCEC are the cancer types where TRBV7-3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV7-3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.746	<.001	8	view →
BRCA	All	III,IV	+0.656	<.001	6	view →
UCEC	All	IV	+0.860	.025	2	view →
LUSC	All	All	−0.353	.021	2	view →
THCA	All	IV	+0.602	.026	1	view →
COAD	All	III,IV	−0.381	.049	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: TRBV7-3 RNA expression & survival · all TRBV7-3 data types