Across TCGA pan-cancer cohorts, TRBV7-1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRBV7-1 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRBV7-1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TRBV7-1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

HNSC, BLCA, and LUAD are the cancer types where TRBV7-1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.156	0.751	<.001	48	view →
BLCA	OS	Median	All	0.188	0.710	.004	15	view →
LUAD	OS	Median	III,IV	0.057	0.680	<.001	12	view →
SKCM	DFS	Median	All	0.437	0.625	.024	4	view →
UCEC	DFS	Median	All	1.000	0.637	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TRBV7-1 tumor-vs-normal RNA expression · all TRBV7-1 data types