TRBV7-1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TRBV7-1 mutation is significantly associated with the RNA expression of many other genes, with 2,689 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRBV7-1-associated genes across cancer lineages are CEP85, MCPH1-AS1, and FRRS1. Each is linked with TRBV7-1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRBV7-1-to-partner and partner-to-TRBV7-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV7-1→partner) and Y-score (partner→TRBV7-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECCEP85 →+0.813+3.491<.001.00233
UCECMCPH1-AS1 →+0.398+2.627<.001.00632
UCECFRRS1 →+0.871+3.470.001.00232
UCECFUBP1 →+0.586+3.338.007.00532
UCECLRRIQ3 →+0.453+2.627<.001.00632
UCECHPRT1 →+0.663+2.649.001.00532
Each partner links to its Q-omics profile. Showing the 6 strongest of 2,689 associations by consensus.

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