Across TCGA patient cohorts, TRBV7-1 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRBV7-1-associated genes across cancer lineages are PDCD4, EGFR_pY1173, and MEK1. Each is linked with TRBV7-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV7-1-to-partner and partner-to-TRBV7-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV7-1→partner) and Y-score (partner→TRBV7-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.938	-3.160	<.001	.019	3	2
UCEC	EGFR_pY1173 →	+0.094	+2.348	.019	.019	3	1
UCEC	MEK1 →	+0.388	+2.321	.034	.035	3	1
UCEC	mTOR_pS2448 →	-0.175	-3.302	.019	.010	3	1
UCEC	N-Cadherin →	+0.331	+2.321	.001	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.680	-2.308	.002	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

TRBV7-1 survival (RNA) · tumor vs normal (RNA) · all TRBV7-1 data types