Across TCGA pan-cancer cohorts, TRBV5-7 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRBV5-7’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV5-7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV5-7 is over-expressed in tumor, although a few such as COAD and PAAD show the opposite, repressed pattern.

KIRC, COAD, and PAAD are the cancer types where TRBV5-7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV5-7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.110	<.001	5	view →
COAD	Female	All	−0.129	.026	4	view →
PAAD	Female	All	−0.500	.045	2	view →
STAD	Female	III,IV	+0.245	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TRBV5-7 RNA expression & survival · all TRBV5-7 data types