Across TCGA pan-cancer cohorts, TRBV5-3 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRBV5-3’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV5-3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV5-3 is over-expressed in tumor.
KIRC, UCEC, and STAD are the cancer types where TRBV5-3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV5-3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.