Across TCGA pan-cancer cohorts, TRBV5-1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TRBV5-1 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher TRBV5-1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRBV5-1 expression acts as an unfavorable survival marker.

LUAD, LUSC, and CESC are the cancer types where TRBV5-1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.466	0.815	<.001	32	view →
LUSC	DFS	Median	All	0.079	0.792	<.001	24	view →
CESC	DFS	Median	All	0.226	0.740	.017	12	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TRBV5-1 tumor-vs-normal RNA expression · all TRBV5-1 data types