Across TCGA patient cohorts, TRBV5-1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRBV5-1-associated genes across cancer lineages are PCNA, EGFR_pY1068, and INPP4B. Each is linked with TRBV5-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV5-1-to-partner and partner-to-TRBV5-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV5-1→partner) and Y-score (partner→TRBV5-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.332	+2.321	.002	.035	3	2
UCEC	EGFR_pY1068 →	-0.282	-2.321	.025	.035	3	1
UCEC	INPP4B →	-0.339	-3.169	.036	.019	3	1
UCEC	Ku80 →	+0.286	+2.335	.015	.020	3	1
UCEC	Myosin-IIa_pS1943 →	+0.334	+3.472	.001	.002	3	1
UCEC	Notch1 →	+0.239	+3.179	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

TRBV5-1 survival (RNA) · tumor vs normal (RNA) · all TRBV5-1 data types