Across TCGA patient cohorts, TRBV4-2 mutation is significantly associated with the RNA expression of many other genes, with 950 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRBV4-2-associated genes across cancer lineages are POLD2, GNPDA1, and ECHS1. Each is linked with TRBV4-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV4-2-to-partner and partner-to-TRBV4-2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV4-2→partner) and Y-score (partner→TRBV4-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	POLD2 →	+0.470	+2.421	.001	.002	3	2
SKCM	GNPDA1 →	+0.429	+1.951	.003	.009	3	2
SKCM	ECHS1 →	+0.407	+2.751	<.001	.002	3	2
SKCM	PGAP6 →	+0.690	+1.938	<.001	.009	3	2
SKCM	SLC43A3 →	+0.733	+1.925	.001	.009	3	2
SKCM	ERP27 →	-0.754	-2.690	.009	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 950 associations by consensus.

Exploration

TRBV4-2 survival (RNA) · tumor vs normal (RNA) · all TRBV4-2 data types