Across TCGA patient cohorts, TRBV4-2 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRBV4-2-associated genes across cancer lineages are FOXO3a_pS318_S321, GSK-3a-b_pS21_S9, and Rb_pS807_S811. Each is linked with TRBV4-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV4-2-to-partner and partner-to-TRBV4-2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV4-2→partner) and Y-score (partner→TRBV4-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FOXO3a_pS318_S321 →	+0.246	+2.017	<.001	.018	3	1
SKCM	GSK-3a-b_pS21_S9 →	+0.487	+3.459	.009	.005	3	1
SKCM	Rb_pS807_S811 →	+0.536	+3.000	.005	.034	3	1
SKCM	Src →	-0.237	-2.000	.021	.031	3	1
SKCM	Tuberin_pT1462 →	+0.345	+2.700	.006	.006	3	1
SKCM	Bad_pS112 →	+0.163	+2.182	.049	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

TRBV4-2 survival (RNA) · tumor vs normal (RNA) · all TRBV4-2 data types