Across TCGA patient cohorts, TRBV28 mutation is significantly associated with the RNA expression of many other genes, with 194 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRBV28-associated genes across cancer lineages are EPHA4, TCTN3, and ASCC1. Each is linked with TRBV28 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV28-to-partner and partner-to-TRBV28 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV28→partner) and Y-score (partner→TRBV28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	EPHA4 →	-0.914	-3.575	.006	.002	3	2
SKCM	TCTN3 →	+0.388	+3.195	.005	.009	3	2
SKCM	ASCC1 →	+0.371	+2.591	.005	<.001	3	2
UCEC	CCL27 →	+0.049	+4.662	<.001	.003	3	2
UCEC	RNA5SP367 →	+0.614	+2.783	.002	.008	3	2
SKCM	SLC25A30 →	+0.569	+2.093	.008	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 194 associations by consensus.

Exploration

TRBV28 survival (RNA) · tumor vs normal (RNA) · all TRBV28 data types