Across TCGA patient cohorts, TRBV19 mutation is significantly associated with the RNA expression of many other genes, with 218 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRBV19-associated genes across cancer lineages are MIR378E, MIR4701, and MIR6089. Each is linked with TRBV19 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRBV19-to-partner and partner-to-TRBV19 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRBV19→partner) and Y-score (partner→TRBV19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR378E →	+0.341	+3.868	<.001	.001	3	2
UCEC	MIR4701 →	+0.832	+2.515	.003	.007	3	2
SKCM	MIR6089 →	+0.175	+4.219	<.001	.006	3	1
SKCM	MIR7845 →	+0.363	+2.864	<.001	.006	3	1
SKCM	MIR6738 →	+0.563	+2.557	<.001	.006	3	1
SKCM	MIR8067 →	+0.205	+3.993	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 218 associations by consensus.

Exploration

TRBV19 survival (RNA) · tumor vs normal (RNA) · all TRBV19 data types