TRBV14

Across TCGA pan-cancer cohorts, TRBV14 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRBV14’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRBV14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRBV14 is over-expressed in tumor, although a few such as LUSC and COAD show the opposite, repressed pattern.

KIRC, LUSC, and COAD are the cancer types where TRBV14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	+0.887	<.001	11	view →
LUSC	All	All	−0.455	<.001	7	view →
COAD	All	II,III,IV	−0.437	<.001	6	view →
THCA	All	All	−0.403	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TRBV14–KIRC

Open the KIRC breakdown →