TRBV13

Across TCGA pan-cancer cohorts, TRBV13 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated TRBV13 data layer.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TRBV13 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRBV13 expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and BRCA are the cancer types where TRBV13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.415	0.268	<.001	120	view →
HNSC	DFS	Median	All	0.759	0.631	<.001	93	view →
BRCA	OS	Median	II,III,IV	0.634	0.495	<.001	92	view →
UVM	OS	Quartile	All	0.354	0.700	<.001	82	view →
LUAD	DFS	Median	All	0.837	0.741	<.001	74	view →
CESC	DFS	Tertile	II,III,IV	0.822	0.594	.012	42	view →
KIRC	DFS	Median	IV	0.220	0.499	.001	36	view →
KIRP	DFS	Tertile	III,IV	0.120	0.615	.003	27	view →
ACC	DFS	Tertile	III,IV	0.010	0.364	<.001	27	view →
ESCA	DFS	Median	II,III,IV	0.604	0.439	.013	26	view →
LIHC	OS	Quartile	All	0.903	0.724	<.001	26	view →
BLCA	OS	Quartile	III,IV	0.771	0.617	.007	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

TRBV13–SKCM (OS)

Open the SKCM breakdown →