TRBV12-4

Across TCGA pan-cancer cohorts, TRBV12-4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TRBV12-4 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRBV12-4 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRBV12-4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, CESC, and SKCM are the cancer types where TRBV12-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.750	0.639	<.001	136	view →
CESC	DFS	Median	All	0.835	0.634	<.001	108	view →
SKCM	OS	Median	All	0.413	0.283	<.001	104	view →
LUAD	DFS	Tertile	All	0.864	0.746	<.001	85	view →
UVM	DFS	Tertile	All	0.512	0.875	<.001	80	view →
BLCA	OS	Median	IV	0.767	0.341	<.001	65	view →
OV	OS	Tertile	II,III,IV	0.440	0.305	.003	62	view →
BRCA	DFS	Median	All	0.569	0.484	.002	41	view →
UCEC	OS	Quartile	III,IV	0.793	0.380	.003	40	view →
PAAD	DFS	Quartile	II,III,IV	0.501	0.263	.006	31	view →
LGG	OS	Quartile	All	0.831	0.915	.003	31	view →
GBM	DFS	Median	All	0.190	0.312	.006	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TRBV12-4–HNSC (DFS)

Open the HNSC breakdown →