TRBV12-1

Across TCGA pan-cancer cohorts, TRBV12-1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated TRBV12-1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher TRBV12-1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRBV12-1 expression acts as an unfavorable survival marker, although some lineages such as LAML and SKCM show a favorable association.

BLCA, UCEC, and KIRP are the cancer types where TRBV12-1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	IV	0.187	0.491	.001	42	view →
UCEC	OS	Tertile	All	0.442	0.751	<.001	42	view →
KIRP	DFS	Tertile	All	0.653	0.911	.013	36	view →
LAML	DFS	Tertile	All	0.744	0.501	.004	26	view →
SKCM	DFS	Tertile	All	0.349	0.193	.017	21	view →
THYM	OS	Median	All	1.000	0.736	.001	20	view →
UVM	DFS	Tertile	All	0.257	0.751	.015	18	view →
LUAD	DFS	Tertile	IV	0.342	0.893	<.001	18	view →
LIHC	OS	Tertile	III,IV	0.093	0.615	<.001	18	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	9	view →
LGG	OS	Tertile	All	0.678	0.909	.023	6	view →
KIRC	OS	Tertile	All	0.756	0.812	.043	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

TRBV12-1–BLCA (DFS)

Open the BLCA breakdown →