TRBV11-3

Across TCGA pan-cancer cohorts, TRBV11-3 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated TRBV11-3 data layer.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher TRBV11-3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRBV11-3 expression acts as an unfavorable survival marker, although some lineages such as CESC and SKCM show a favorable association.

CESC, UVM, and KIRP are the cancer types where TRBV11-3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Median	All	0.841	0.627	<.001	108	view →
UVM	OS	Tertile	II,III,IV	0.343	0.788	<.001	96	view →
KIRP	DFS	Quartile	II,III,IV	0.169	0.848	<.001	87	view →
SKCM	OS	Median	All	0.421	0.253	<.001	48	view →
LGG	OS	Tertile	All	0.234	0.474	<.001	42	view →
HNSC	DFS	Tertile	All	0.775	0.654	.002	34	view →
LIHC	DFS	Tertile	All	0.394	0.235	.012	26	view →
LUAD	DFS	Median	II,III,IV	0.694	0.458	.001	21	view →
THYM	OS	Median	All	1.000	0.702	<.001	20	view →
STAD	DFS	Median	III,IV	0.668	0.475	.007	18	view →
BRCA	DFS	Quartile	All	0.575	0.496	.004	13	view →
OV	DFS	Quartile	All	0.604	0.516	.039	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

TRBV11-3–CESC (DFS)

Open the CESC breakdown →