TRBV11-2

Across TCGA pan-cancer cohorts, TRBV11-2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TRBV11-2 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRBV11-2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated TRBV11-2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and SKCM are the cancer types where TRBV11-2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.435	0.276	<.001	140	view →
BLCA	OS	Tertile	IV	0.745	0.476	<.001	115	view →
SKCM	OS	Median	All	0.417	0.269	<.001	96	view →
LGG	OS	Tertile	All	0.666	0.862	<.001	54	view →
OV	DFS	Quartile	II,III,IV	0.456	0.337	.007	50	view →
UVM	OS	Median	All	0.423	0.713	.003	41	view →
CESC	DFS	Median	All	0.812	0.665	.002	30	view →
BRCA	DFS	Tertile	All	0.636	0.487	.003	24	view →
SARC	OS	Median	All	0.820	0.662	<.001	24	view →
LIHC	DFS	Quartile	All	0.624	0.380	.001	19	view →
THYM	OS	Tertile	All	1.000	0.694	.001	17	view →
LUAD	DFS	Quartile	All	0.753	0.629	.015	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

TRBV11-2–HNSC (OS)

Open the HNSC breakdown →