TRBV1

Across TCGA pan-cancer cohorts, TRBV1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRBV1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TRBV1 RNA is repressed in tumor relative to normal tissue. In most cancer types TRBV1 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and UCEC are the cancer types where TRBV1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRBV1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	−0.104	<.001	7	view →
THCA	All	All	−0.137	.012	3	view →
UCEC	All	IV	+0.465	.031	2	view →
LUAD	All	IV	−0.435	<.001	2	view →
KIRC	Female	All	+0.086	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TRBV1–COAD

Open the COAD breakdown →