Across TCGA pan-cancer cohorts, TRAV8-6 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TRAV8-6 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRAV8-6 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRAV8-6 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where TRAV8-6 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.682	0.518	<.001	154	view →
SKCM	OS	Median	All	0.434	0.256	<.001	123	view →
UVM	OS	Tertile	All	0.344	0.736	<.001	86	view →
LUAD	DFS	Tertile	All	0.886	0.711	<.001	71	view →
BRCA	DFS	Tertile	All	0.964	0.918	<.001	63	view →
CESC	OS	Tertile	II,III,IV	0.940	0.697	.002	60	view →
BLCA	OS	Median	III,IV	0.446	0.271	.002	54	view →
LGG	OS	Tertile	All	0.314	0.500	<.001	49	view →
LIHC	DFS	Tertile	All	0.643	0.455	<.001	41	view →
UCEC	DFS	Tertile	All	0.880	0.788	.012	32	view →
OV	DFS	Median	All	0.192	0.132	.018	30	view →
LUSC	DFS	Tertile	III,IV	0.489	0.189	.008	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

Exploration

Same gene, other analysis: TRAV8-6 tumor-vs-normal RNA expression · all TRAV8-6 data types