TRAV8-5

Across TCGA pan-cancer cohorts, TRAV8-5 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated TRAV8-5 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRAV8-5 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRAV8-5 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CESC show a favorable association.

HNSC, CESC, and UVM are the cancer types where TRAV8-5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.679	0.526	<.001	144	view →
CESC	OS	Median	All	0.677	0.498	<.001	86	view →
UVM	OS	Tertile	III,IV	0.612	0.857	.012	65	view →
BRCA	DFS	Quartile	All	0.972	0.914	<.001	55	view →
KIRC	DFS	Quartile	III,IV	0.572	0.269	<.001	44	view →
LUAD	DFS	Tertile	All	0.753	0.616	.001	30	view →
ESCA	DFS	Median	II,III,IV	1.000	0.388	.010	26	view →
LGG	DFS	Tertile	All	0.804	0.673	.002	21	view →
ACC	OS	Tertile	III,IV	0.260	0.667	.012	18	view →
THYM	OS	Tertile	II,III,IV	1.000	0.651	.003	17	view →
MESO	OS	Median	IV	0.826	0.399	.003	12	view →
LAML	DFS	Tertile	All	0.445	0.737	.018	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

TRAV8-5–HNSC (DFS)

Open the HNSC breakdown →