Across TCGA patient cohorts, TRAV8-4 mutation is significantly associated with the RNA expression of many other genes, with 326 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRAV8-4-associated genes across cancer lineages are RNU6-706P, ATP2B2-IT1, and MIR7973-1. Each is linked with TRAV8-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAV8-4-to-partner and partner-to-TRAV8-4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAV8-4→partner) and Y-score (partner→TRAV8-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-706P →	+0.283	+7.954	<.001	.008	3	2
UCEC	ATP2B2-IT1 →	+0.073	+4.260	<.001	.007	3	2
SKCM	MIR7973-1 →	+0.235	+2.877	<.001	.009	3	1
SKCM	ACACA →	+0.460	+2.328	.008	.003	3	1
BLCA	LINC02423 →	+0.099	+7.640	<.001	.009	3	1
BLCA	OR4G6P →	+0.044	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 326 associations by consensus.

Exploration

TRAV8-4 survival (RNA) · tumor vs normal (RNA) · all TRAV8-4 data types