Across TCGA patient cohorts, TRAV8-4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRAV8-4-associated genes across cancer lineages are FOXO3a_pS318_S321, NDRG1_pT346, and Di-Ras3. Each is linked with TRAV8-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAV8-4-to-partner and partner-to-TRAV8-4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAV8-4→partner) and Y-score (partner→TRAV8-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FOXO3a_pS318_S321 →	+0.230	+2.820	<.001	.035	3	1
SKCM	NDRG1_pT346 →	+0.909	+2.459	.003	.020	3	1
SKCM	Di-Ras3 →	+0.145	+2.459	.033	.020	3	1
SKCM	PKC-delta_pS664 →	+0.185	+2.459	.038	.020	2	1
SKCM	Shc_pY317 →	+0.257	+2.476	.004	.010	1	1
SKCM	TIGAR →	-0.182	-3.584	.003	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

TRAV8-4 survival (RNA) · tumor vs normal (RNA) · all TRAV8-4 data types