Across TCGA patient cohorts, TRAV8-2 mutation is significantly associated with the RNA expression of many other genes, with 91 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TRAV8-2-associated genes across cancer lineages are MIR548AK, FAM138A, and RNU6-1213P. Each is linked with TRAV8-2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAV8-2-to-partner and partner-to-TRAV8-2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAV8-2→partner) and Y-score (partner→TRAV8-2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MIR548AK →	+0.502	+5.505	<.001	.004	3	2
SKCM	FAM138A →	+0.012	+4.219	.002	.006	3	2
UCEC	RNU6-1213P →	+0.290	+4.069	<.001	.008	3	2
SKCM	RNU1-49P →	+0.255	+3.993	<.001	.008	3	2
HNSC	OR4C2P →	+0.034	+6.468	.002	.001	3	1
HNSC	RNA5SP273 →	+0.408	+6.008	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 91 associations by consensus.

Exploration

TRAV8-2 survival (RNA) · tumor vs normal (RNA) · all TRAV8-2 data types