Across TCGA pan-cancer cohorts, TRAV8-1 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TRAV8-1 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in sarcoma (SARC), where higher TRAV8-1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRAV8-1 expression acts as an unfavorable survival marker.

SARC and SKCM are the cancer types where TRAV8-1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SARC	DFS	Median	All	0.158	0.613	.013	6	view →
SKCM	DFS	Median	All	0.060	0.207	.024	5	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TRAV8-1 tumor-vs-normal RNA expression · all TRAV8-1 data types