TRAV8-1

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TRAV8-1 mutation is significantly associated with the RNA expression of many other genes, with 166 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAV8-1-associated genes across cancer lineages are RNA5SP411, RNA5SP413, and RNU7-90P. Each is linked with TRAV8-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAV8-1-to-partner and partner-to-TRAV8-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAV8-1→partner) and Y-score (partner→TRAV8-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRNA5SP411 →+1.735+2.656<.001.00332
LUADRNA5SP413 →+0.188+7.930<.001.00832
UCECRNU7-90P →+0.351+3.356<.001.00532
HNSCMDH1P1 →+0.041+5.069.001.00832
HNSCOR1D5 →+0.057+5.124<.001.00832
LUSCRDXP2 →+0.358+5.211<.001.00732
Each partner links to its Q-omics profile. Showing the 6 strongest of 166 associations by consensus.

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