Across TCGA pan-cancer cohorts, TRAV41 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of TRAV41’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAV41 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAV41 is over-expressed in tumor, although a few such as LUAD and LUSC show the opposite, repressed pattern.
KIRC, LUAD, and BRCA are the cancer types where TRAV41 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAV41 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.