Across TCGA pan-cancer cohorts, TRAV35 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRAV35’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAV35 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAV35 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

KIRC, BRCA, and COAD are the cancer types where TRAV35 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAV35 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.572	<.001	11	view →
BRCA	All	IV	+0.225	<.001	6	view →
COAD	Female	All	−0.321	.037	2	view →
STAD	Female	III,IV	+1.635	.036	1	view →
KICH	Female	II,III,IV	−0.175	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TRAV35 RNA expression & survival · all TRAV35 data types