Across TCGA pan-cancer cohorts, TRAV3 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRAV3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAV3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAV3 is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

KIRC, LUSC, and BRCA are the cancer types where TRAV3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAV3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+1.073	<.001	11	view →
LUSC	All	II,III,IV	−0.536	.006	5	view →
BRCA	All	All	+0.264	.010	4	view →
THCA	All	All	−0.420	.006	3	view →
COAD	All	All	−0.363	.022	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TRAV3 RNA expression & survival · all TRAV3 data types