Across TCGA pan-cancer cohorts, TRAV21 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated TRAV21 data layer compared with 1 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRAV21 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated TRAV21 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where TRAV21 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.398	0.251	<.001	106	view →
SKCM	OS	Median	All	0.418	0.268	<.001	99	view →
UVM	OS	Tertile	II,III,IV	0.369	0.741	<.001	95	view →
LUAD	DFS	Median	All	0.734	0.600	<.001	86	view →
BRCA	DFS	Median	All	0.607	0.462	<.001	83	view →
UCEC	DFS	Quartile	All	0.923	0.803	.001	72	view →
CESC	DFS	Quartile	II,III,IV	0.871	0.607	.008	52	view →
OV	DFS	Tertile	All	0.587	0.478	.010	50	view →
KIRC	DFS	Tertile	II,III,IV	0.602	0.393	.003	39	view →
LIHC	DFS	Median	All	0.617	0.470	<.001	30	view →
ACC	OS	Tertile	III,IV	0.468	0.852	<.001	27	view →
COAD	DFS	Tertile	II,III,IV	0.744	0.614	.019	24	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

Exploration

Same gene, other analysis: TRAV21 tumor-vs-normal RNA expression · all TRAV21 data types