Across TCGA patient cohorts, TRAV18 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAV18-associated genes across cancer lineages are MEK1, Tuberin, and Cyclin-B1. Each is linked with TRAV18 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAV18-to-partner and partner-to-TRAV18 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAV18→partner) and Y-score (partner→TRAV18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.654	+3.000	.001	.036	3	1
UCEC	Tuberin →	+0.428	+2.817	.006	.036	3	1
UCEC	Cyclin-B1 →	+0.758	+3.000	.019	.037	3	1
SKCM	Annexin-1 →	+0.740	+3.000	.005	.036	3	1
SKCM	Smad4 →	+0.136	+3.000	.035	.036	3	1
SKCM	CD49b →	+0.643	+3.017	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Exploration

TRAV18 survival (RNA) · tumor vs normal (RNA) · all TRAV18 data types