Across TCGA pan-cancer cohorts, TRAV14DV4 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRAV14DV4’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAV14DV4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAV14DV4 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

KIRC, COAD, and LUSC are the cancer types where TRAV14DV4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAV14DV4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+1.115	<.001	11	view →
COAD	Female	All	−0.859	.001	6	view →
LUSC	Male	All	−0.496	.002	5	view →
THCA	All	All	−0.304	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TRAV14DV4 RNA expression & survival · all TRAV14DV4 data types