Across TCGA patient cohorts, TRAV12-1 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAV12-1-associated genes across cancer lineages are p90 RSK_pT359_S363, Myosin-IIa_pS1943, and STAT3_pY705. Each is linked with TRAV12-1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAV12-1-to-partner and partner-to-TRAV12-1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAV12-1→partner) and Y-score (partner→TRAV12-1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	p90 RSK_pT359_S363 →	-0.170	-2.321	.045	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.243	+3.183	.031	.010	3	1
UCEC	STAT3_pY705 →	-0.435	-2.999	.002	.035	3	1
UCEC	ACC1 →	+0.613	+3.169	.002	.020	2	1
UCEC	AR →	-0.622	-3.169	.002	.020	2	1
UCEC	EGFR_pY1068 →	-0.430	-3.169	.001	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Exploration

TRAV12-1 survival (RNA) · tumor vs normal (RNA) · all TRAV12-1 data types