TRAPPC9

Across TCGA patient cohorts, TRAPPC9 mutation is significantly associated with the total protein of many other genes, with 59 significant associations in total. COAD shows the largest number of these associations.

The most reproducible TRAPPC9-associated genes across cancer lineages are MIG-6, Lck, and MEK1. Each is linked with TRAPPC9 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRAPPC9-to-partner and partner-to-TRAPPC9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by TRAPPC9-low versus TRAPPC9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC9→partner) and Y-score (partner→TRAPPC9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIG-6 →	+0.137	+2.932	.024	<.001	3	4
COAD	Lck →	+0.484	+2.610	<.001	.005	3	4
UCEC	MEK1 →	+0.466	+2.999	<.001	<.001	3	3
UCEC	ATM →	-0.492	-3.571	.001	.002	3	3
COAD	Caspase-7-cleavedD198 →	+1.417	+2.338	<.001	.017	3	3
COAD	GSK-3_pS9 →	-0.372	-2.321	.023	.033	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

MIG-6 by TRAPPC9 expression — SKCM

Explore this box plot interactively →