TRAPPC8

Across TCGA patient cohorts, TRAPPC8 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAPPC8-associated genes across cancer lineages are FASN, GAPDH, and 4E-BP1. Each is linked with TRAPPC8 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRAPPC8-to-partner and partner-to-TRAPPC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by TRAPPC8-low versus TRAPPC8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC8→partner) and Y-score (partner→TRAPPC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.218	+1.222	.042	.032	3	4
UCEC	GAPDH →	+0.346	+1.765	.018	.011	3	3
UCEC	4E-BP1 →	+0.338	+3.392	<.001	<.001	3	3
UCEC	14-3-3_beta →	-0.068	-1.335	.013	.031	3	2
UCEC	eIF4E →	+0.152	+3.100	.008	<.001	3	2
UCEC	eIF4G →	+0.220	+1.584	.009	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

FASN by TRAPPC8 expression — UCEC

Explore this box plot interactively →