TRAPPC8

Across TCGA cell cohorts, TRAPPC8 mutation is significantly associated with the RNA expression of many other genes, with 770 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRAPPC8-associated genes across cancer lineages are CARD17, SMIM23, and GSG1L2. Each is linked with TRAPPC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAPPC8-to-partner and partner-to-TRAPPC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARD17 grouped by TRAPPC8-low versus TRAPPC8-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC8→partner) and Y-score (partner→TRAPPC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	CARD17 →	+0.282	+4.977	<.001	.002	3	2
SKIN	SMIM23 →	+0.018	+4.437	<.001	.004	3	2
BLOOD_Leukemia	GSG1L2 →	+0.034	+4.384	<.001	.006	3	2
SOFT_TISSUE	AGXT2 →	+0.889	+4.222	<.001	.007	3	1
SOFT_TISSUE	OR4X2 →	+0.013	+4.369	.006	.008	3	1
SOFT_TISSUE	OR52J3 →	+0.019	+4.369	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 770 associations by consensus.

CARD17 by TRAPPC8 expression — SOFT_TISSUE

Explore this box plot interactively →