TRAPPC6B

Across TCGA patient cohorts, TRAPPC6B mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAPPC6B-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and IRS1. Each is linked with TRAPPC6B in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAPPC6B-to-partner and partner-to-TRAPPC6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by TRAPPC6B-low versus TRAPPC6B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC6B→partner) and Y-score (partner→TRAPPC6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.336	-2.321	.007	.035	3	1
UCEC	A-Raf_pS299 →	-0.135	-3.321	.024	.010	3	1
UCEC	IRS1 →	+0.243	+2.321	.019	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.177	-2.308	.037	.036	3	1
UCEC	MEK1 →	+0.382	+2.321	.037	.035	3	1
UCEC	MIG-6 →	+0.107	+2.335	.031	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by TRAPPC6B expression — UCEC

Explore this box plot interactively →