TRAPPC6A

Across TCGA pan-cancer cohorts, TRAPPC6A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated TRAPPC6A data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher TRAPPC6A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRAPPC6A expression acts as an unfavorable survival marker, although some lineages such as DLBC and LUSC show a favorable association.

ACC, UCS, and DLBC are the cancer types where TRAPPC6A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	All	0.268	0.735	<.001	65	view →
UCS	OS	Quartile	III,IV	0.321	0.794	.001	32	view →
DLBC	DFS	Tertile	All	1.000	0.465	.012	25	view →
BRCA	DFS	Median	All	0.463	0.596	.011	24	view →
LUSC	OS	Quartile	All	0.830	0.704	.008	24	view →
KIRC	DFS	Quartile	All	0.681	0.458	<.001	22	view →
READ	DFS	Median	All	0.762	0.897	.012	18	view →
SCLC	DFS	Median	IV	0.651	0.148	.006	16	view →
HNSC	OS	Median	All	0.494	0.696	.014	14	view →
SARC	DFS	Quartile	All	0.652	0.274	.003	13	view →
SKCM	OS	Median	III,IV	0.315	0.524	.008	12	view →
MESO	DFS	Quartile	III,IV	0.669	0.165	.017	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

TRAPPC6A–ACC (DFS)

Open the ACC breakdown →