TRAPPC5

Across TCGA patient cohorts, TRAPPC5 mutation is significantly associated with the RNA expression of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAPPC5-associated genes across cancer lineages are MIR548AP, NF1P10, and DEFB103A. Each is linked with TRAPPC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAPPC5-to-partner and partner-to-TRAPPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548AP grouped by TRAPPC5-low versus TRAPPC5-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC5→partner) and Y-score (partner→TRAPPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR548AP →	+0.317	+8.055	<.001	.007	3	1
UCEC	NF1P10 →	+0.230	+3.778	.004	.007	3	1
BRCA	DEFB103A →	+0.069	+8.055	<.001	.007	3	1
BRCA	MIR509-3 →	+0.386	+8.055	<.001	.007	3	1
BRCA	MGAT2P2 →	+0.044	+9.057	<.001	.003	3	1
LUAD	RNU6-486P →	+0.342	+7.930	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

MIR548AP by TRAPPC5 expression — BRCA

Explore this box plot interactively →