TRAPPC5

Across TCGA cell cohorts, TRAPPC5 mutation is significantly associated with the drug of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRAPPC5-associated genes across cancer lineages are IC-87114, CX-5461, and GSK690693. Each is linked with TRAPPC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAPPC5-to-partner and partner-to-TRAPPC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IC-87114 grouped by TRAPPC5-low versus TRAPPC5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC5→partner) and Y-score (partner→TRAPPC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IC-87114 →	+0.256	+2.652	.012	.045	3	1
LARGE_INTESTINE	CX-5461 →	+0.644	+2.652	.029	.045	3	1
LARGE_INTESTINE	GSK690693 →	+0.819	+2.791	<.001	.028	3	1
LARGE_INTESTINE	TWS119 →	+0.513	+2.652	.029	.045	3	1
LARGE_INTESTINE	kb NB 142-70 →	+0.493	+2.652	.037	.045	3	1
LARGE_INTESTINE	FY012 →	+0.438	+2.649	.034	.046	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

IC-87114 by TRAPPC5 expression — LARGE_INTESTINE

Explore this box plot interactively →