TRAPPC3

Across TCGA pan-cancer cohorts, TRAPPC3 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of TRAPPC3’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where TRAPPC3 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types TRAPPC3 is over-expressed in tumor, although a few such as CCRCC and COAD show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where TRAPPC3 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAPPC3 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−0.383	<.001	11	view →
HNSC	All	II,III,IV	+0.206	<.001	11	view →
COAD	Male	III,IV	−0.291	<.001	10	view →
PDAC	Male	II,III,IV	+0.469	<.001	6	view →
LUAD	Female	All	+0.159	<.001	6	view →
LSCC	Female	All	−0.130	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

TRAPPC3–CCRCC

Open the CCRCC breakdown →