TRAPPC2B

Across TCGA patient cohorts, TRAPPC2B mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAPPC2B-associated genes across cancer lineages are ASNS, FoxM1, and INPP4B. Each is linked with TRAPPC2B in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAPPC2B-to-partner and partner-to-TRAPPC2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TRAPPC2B-low versus TRAPPC2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC2B→partner) and Y-score (partner→TRAPPC2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.516	+3.000	.006	.036	3	2
UCEC	FoxM1 →	+0.451	+3.179	<.001	.010	3	1
UCEC	INPP4B →	-0.388	-2.999	.022	.035	3	1
UCEC	STAT3_pY705 →	-0.488	-2.999	<.001	.035	3	1
UCEC	C-Raf →	+0.309	+3.169	<.001	.019	3	1
UCEC	eIF4E →	+0.240	+3.321	.030	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ASNS by TRAPPC2B expression — UCEC

Explore this box plot interactively →